Candidates for organ transplant are thoroughly screened, and illicit substance use is usually disqualifying. But cannabis is well established as a medicine (as it has been for millennia) and should not prevent patients from receiving a necessary transplant. Doctors at a pediatric hospital in Delaware recently described the thought process around allowing or prohibiting cannabis use. An adolescent woman was managing her anxiety with cannabis and had a kidney disease.
Organophosphates are a class of insecticides like chlorpyrifos and soman. Sarin, used as a chemical weapon, is also an organophosphate. Many of these are neurotoxic, owing to their ability to amplify the neurotransmitter acetylcholine, which paralyzes insects and causes their death. A recent study from medical researchers in Maryland and Pennsylvania described the human toxicity in detail and explained why cannabinoids may be protective for humans.
Synthetic cannabinoids (sCBs) are a class of designer drugs meant to interact with the endocannabinoid system. Going by names like spice and K2, they are used largely as a result of prohibition — many sCBs are technically legal and difficult to detect, so people will not be punished for use as they would be for smoking cannabis. Many synthetic cannabinoids are also used as research tools, allowing scientists to probe the role of the endocannabinoid system in disease when they cannot get legal access to THC or cannabis.