Cannabinoids play a diverse role in addiction. They confer some of the euphoric feelings of many drugs, but also help eliminate memories that trigger cravings. The also regulate dopamine in a part of the brain called the ventral tegmental area (VTA). Normally, dopamine release in the VTA helps orient animals, including humans, to new kinds of stimuli.
Project CBD submitted this public comment, composed by Adrian Devitt-Lee, to California’s Office of Environmental Health Hazard Assessment (OEHHA), which administers the Proposition 65 Program. Approved as a 1986 ballot measure, Proposition 65 requires the state to maintain and update a list of chemicals known to cause cancer or reproductive toxicity.
When a receptor is overactive — because of a drug or disease — the body attempts to normalize activity by internalizing the receptor, hiding it from molecules at the cell surface. Internalization is a key homeostatic mechanism. But a receptor’s degree of activation doesn’t perfectly parallel the subsequent internalization. Some ligands are «biased,» preferring activation over desensitization, or vice versa.