CB1 and learning

Learning involves both forging new neural connections and pruning ones that are no longer necessary. Blocking CB1 activation may impair learning ability by blocking its ability to prune unhelpful connections.

CB1 Kinetics

When a receptor is overactive — because of a drug or disease — the body attempts to normalize activity by internalizing the receptor, hiding it from molecules at the cell surface. Internalization is a key homeostatic mechanism. But a receptor’s degree of activation doesn’t perfectly parallel the subsequent internalization.