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Preventing Pain with Orphan Receptors

Phytocannabinoids consistently confuse scientists because of the multiplicity of their actions. CBD, for example, binds to a handful of neurotransmitter receptors, as well as hormone receptors, ion channels, and a variety of enzymes. Receptors without a known endogenous ligand are called «orphan» receptors. GPR18 is involved in ocular-pressure (and hence glaucoma treatment) as well as cardiovascular function.

THC Makes Oxycodone Safer

Many prohibitionist arguments are being flipped on their heads. CBD’s anti-anxiety effects have replaced much of the reefer madness mentality. Rather than causing lung cancer, marijuana appears to have anti-cancer activity, if anything. And in spite of the gateway theory, whereby casual cannabis use supposedly escalates to heroin, we find that cannabis helps to treat pain and reduce opiate use.

Placebo Genetics

Placebo effect cannabinoid receptors

Throughout history, cannabis has been described as a treatment for hundreds of different conditions. If scientists find it hard to believe cannabis can do so much, they may chalk up the results as just a placebo. But the placebo effect is powerful. It accounts for roughly half of the efficacy of opioids and antidepressants.

CBD & Cannabis for Pets in Pain

A mall black and white dog looks at the camera while a vet takes notes on a yellow folder in the background.

The state of veterinary medicine has advanced significantly in recent years and thanks to the availability of more effective medicine, many pets are living longer than they would have years ago. With age however, comes the onset of problems such as arthritis and other forms of pain and inflammation. Conventional pharmaceuticals commonly used to treat pain sometimes have a negative impact on the immune system, GI tract, liver, and kidneys. Additionally, they don’t always work as well as we would like them to – for humans as well as our pets.1

FAAH Mutation & Pain Insensitivity

There are curious cases of people who feel no pain or have extreme resistance to discomfort. These individuals are often studied by researchers who hope to develop better methods of pain management. One such woman was discovered after she recovered from a highly painful wrist surgery using Tylenol alone. As researchers at the University College of London found out, she had a history of this sort of endurance, and it appeared to have been passed on to her son. With her consent, they ran genetic tests, identifying two mutation in genes related to FAAH.