Cannabinoids have been proposed for numerous neurodegenerative disorders. As a matter of fact, scientists employed by the US government filed a patent in 2001 for Cannabinoids as antioxidants and neuroprotectants, citing their potential for treating Alzheimer’s disease among others.
The human endocannabinoid system (ECS) is so named because it responds to cannabis compounds. But cannabis is not its only regulator – there are a plethora of molecules derived from plants or even single-cellular organisms that interact with the ECS.
Project CBD speaks with neuroscientist Greg Gerdeman on the endocannabinoid system and the biology of wellness
A pilot study recently demonstrated that cannabis extracts can be safely used to ameliorate symptoms of severe dementia. Swiss researchers at Geneva University Hospitals decided to use cannabinoids to help ten patients with severe dementia. They took a 2:1 extract of CBD and THC, titrating patients up to about 20 mg CBD and 10 mg THC per day. The oil extract was infused into cake to make it more palatable to the seniors, and the dose was split across three meals a day.
Most everyone has had the experience of biting into a spicy pepper and feeling heat permeate their mouth. This feeling comes from the activation of TRPV (pronounced trip-vee) receptors. These are ion channels that sense stimuli like heat, pressure, light, acidity, herbs, and toxins. TRPV receptors exist on many kinds of cells — from taste buds to neurons.
THC and other cannabinoids are known to induce neurogenesis — the creation of new neurons — in the brain. There are reasons to believe that this can positively influence diseases like dementia or traumatic brain injury, as well as the ability to learn. Malaysian researchers recently probed the question, does THC improve cognition by inducing neurogenesis? Yes, but only at the right dose.