Inflammation

Pancreatitis in Cannabis Users

People with pancreatitis who had cannabinoids in their bloodstream were 3-4x less likely to die in the hospital

Ibuprofen as a FAAH Inhibitor

Advil pills

Nonsteroidal antiinflammatory drugs (NSAIDs) are one of the most common classes of painkillers, which includes aspirin, ibuprofen, celecoxib, and other pharmaceuticals. Their primary target is an enzyme called cyclooxygenase-2 (COX-2), which metabolizes many lipids (including endocannabinoids!) into a class of inflammatory molecules called prostaglandins.

Who's in My Entourage?

Sunny marijuana leaf

The entourage effect was a term first used to describe the various endocannabinoids that work together. Recent research emphasizes how two of these chemicals (OEA and PEA) exert subtle anti-inflammatory and antidepressant effects through a receptor called PPAR-alpha. PPAR-alpha regulates gene expression. Many plant cannabinoids - including CBD and THCA - activate the related protein, PPAR-gamma.

Self-Medicating for Endometriosis

Woman sitting up holding belly

Endometriosis is a poorly-understood condition causing severe chronic pain and alterations in a woman’s menstrual cycle. As an understudied disease, treatment is limited. Scientists surveyed over 400 Australian women to see what actions they took to treat their pelvic pain. Cannabis, heat, CBD oil, and dietary changes were rated most effective by women, in that order. Unfortunately, more women used alcohol than cannabis to manage symptoms; self-medicating with alcohol promotes chronic inflammation and led to worsening pain and fatigue in over half of such women.

ICRS 2018: Report from Leiden (Part 2)

During the first week of July 2018, five-hundred-and-thirty-five delegates from five continents met at the University of Leiden in the Netherlands for the 28th annual symposium of the International Cannabinoid Research Society (ICRS). The four-day conference showcased recent scientific discoveries about cannabis components and various ways of targeting the endocannabinoid system to improve health outcomes.

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News & Reports

Top Conditions

In compiling a list of conditions that CBD may help, we examined hundreds of peer-reviewed articles in scientific journals.

Cannabis Conversations

Project CBD talks with Dr. Bonni Goldstein about whole plant cannabis remedies, nonintoxicating cannabinoids, and cancer care for children.
Expert cannabis botanist and geneticist Ryan Lee talks to Project CBD about breeding cannabis, THC & CBD content, and how to interpret lab data.
Project CBD speaks with Dr. Rachel Knox about "endocannabinology," THC/CBD synergies, and whole food nutrition.

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