Robert Randall was the first U.S. citizen to legally access cannabis based on medical necessity since the start of prohibition. He and his wife, Alice O’Leary Randall, sued the government because THC-rich cannabis was the only effective medicine for his glaucoma.
Phytocannabinoids consistently confuse scientists because of the multiplicity of their actions. CBD, for example, binds to a handful of neurotransmitter receptors, as well as hormone receptors, ion channels, and a variety of enzymes. Receptors without a known endogenous ligand are called “orphan” receptors. GPR18 is involved in ocular-pressure (and hence glaucoma treatment) as well as cardiovascular function.
Cannabis Conversations with cannabis pioneer Alice O’Leary Randall on the momentous court case that launched the medical marijuana movement.
Cannabis has been well known to treat eye pressure associated with glaucoma. Now new research indicates that direct topical application of cannabidiol (CBD) may be beneficial for neuropathic ocular pain.