At night you might find Chelsea Leyland, a 31-year-old British celebrity DJ, juggling beats at a flashy Miami party while rocking a Simone Rocha dress that complements her honey-hued hair and brown eyes. By day she shifts into activist mode, traveling the country, giving interviews, talking at conferences and filming a documentary — all on the complex and controversial subject of medical marijuana. Leyland wants people to know how she has overcome a crippling neurological illness.
A variety of different things may happen as a result of a seizure, depending upon the region of the brain that is affected. There may be sudden changes in sensory perception, such as visual disturbances or the smell of an unusual odor. There may be rapid and inexplicable emotional or cognitive changes. There are often involuntary muscle movements, and sometimes even complete loss of control over the movement of one’s body. Obviously, this could lead to serious consequences if someone has a seizure while, for example, driving a car.
Part of why doctors remain wary of cannabis medicine is the lack of randomized, double-blind, placebo controlled trials — the gold standard for medical research. Because of cannabis’ status as an illicit drug, research is often relegated to retrospective surveys, which are useful but more likely to be biased. But there are methods in between these two schemes, such as open-label trials.
How often have we heard, “More research is needed,” from those who would prefer to see no change in policies that should be informed by science? From climate denial to cannabis prohibition, the demand for absolute scientific certainty is a call for inaction.
It begs the question: When is there “enough” research?
New: This report is now available in Spanish and Japanese translations! See bottom of this article for downloads.
Graft-versus-host disease (GVHD) is a common – and potentially fatal – complication following bone marrow and solid organ transplants. This life threatening condition can also occur after a patient receives a blood transfusion or other forms of transplanted tissue from a genetically different person.
“David,” a 10 year old boy, had his first seizure at 2 months of age. The convulsions were photosensitive generalized tonic-clonic seizures that occurred 1-4 times each day. These events were occurring daily, even though he was being treated with two anti-seizure medications – lamotrigine (Lamictal) and valproic acid. But they had already tried carbamazepine, phenobarbital, zonisamide and levetiracetam (Keppra) without success.