Endocannabinoid System

Anandamide Modulates Panic

Rainbow Boa Snake

Panic, as a mental health disorder, results from overactive stress hormones, hypersensitivity to certain neurotransmitters, and a desensitization to the parasympathetic system — which is supposed to quell the fight-or-flight reaction after a threat has disappeared. New research from Brazilian scientsts in São Paulo examined how endocannabinoids, specifically anandamide, plays a role in panic-like reactions in mice.

Lupus and ABHD6

Systemic lupus erythomatosus, often simply called lupus, is a severe autoimmune disorder where the immune system attacks the nucleus of cells — their genetic control center. Problems can be expressed anywhere in the body, though rashes in the skin, joints, and vital organs are most common. Treatment of lupus generally requires intense immunosuppresive drugs, often targeting inflammatory molecules called interferons. But these drugs make a person more susceptible to other diseases.

Ibuprofen as a FAAH Inhibitor

Nonsteroidal antiinflammatory drugs (NSAIDs) are one of the most common classes of painkillers, which includes aspirin, ibuprofen, celecoxib, and other pharmaceuticals. Their primary target is an enzyme called cyclooxygenase-2 (COX-2), which metabolizes many lipids (including endocannabinoids!) into a class of inflammatory molecules called prostaglandins.