Endocannabinoid System

Markers of Endometrial Cancer

endometrial cancer and cbd
Recent research has indicated a role of endocannabinoids in endometriosis and related diseases. A study published in Frontiers in Oncology sought to determine whether endometrial cancer could be predicted by someone’s levels of the two canonical cannabinoid receptors (CB1 and CB2) and three related fatty acids (anandamide, OEA, and PEA).

CB1 Protects Against Pesticide Toxicity

Pesticides on cannabis

Organophosphates are a class of insecticides like chlorpyrifos and soman. Sarin, used as a chemical weapon, is also an organophosphate. Many of these are neurotoxic, owing to their ability to amplify the neurotransmitter acetylcholine, which paralyzes insects and causes their death. A recent study from medical researchers in Maryland and Pennsylvania described the human toxicity in detail and explained why cannabinoids may be protective for humans.

CB1 and Hormone Therapy

Stethoscope on note book with Menopause words as medical concept

Hormone replacement therapy is used to reduce some of the symptoms of menopause. Although it can reduce problems like osteoporosis, hot flashes and depression, hormonal treatments come with risks including an increased likelihood of stroke and heart attack. Among those who use hormone therapy, scientists tend to believe there is a «critical window» where hormone replacement can reduce depression and the worsening memory associated with menopause. A new study from researchers in Xi’an, China, indicates that activating CB1 may prolong this window.

Preventing Pain with Orphan Receptors

Phytocannabinoids consistently confuse scientists because of the multiplicity of their actions. CBD, for example, binds to a handful of neurotransmitter receptors, as well as hormone receptors, ion channels, and a variety of enzymes. Receptors without a known endogenous ligand are called «orphan» receptors. GPR18 is involved in ocular-pressure (and hence glaucoma treatment) as well as cardiovascular function.