Graft Versus Host Disease (GvHD) occurs when the white blood cells in a transplanted organ or bone marrow begin to attack other cells in the recipient’s body. It also occurs, rarely, after some blood transfusions where the blood is not first irradiated. It results in inflammation in various organs, and can increase chances for systemic infection - a dangerous complication.
Scleroderma is an autoimmune disease characterized by the overproduction of collegen and other fibrotic cells. This overproduction generally first appears on the skin, although it can also express systemically.
Systemic lupus erythomatosus, often simply called lupus, is a severe autoimmune disorder where the immune system attacks the nucleus of cells — their genetic control center. Problems can be expressed anywhere in the body, though rashes in the skin, joints, and vital organs are most common. Treatment of lupus generally requires intense immunosuppresive drugs, often targeting inflammatory molecules called interferons. But these drugs make a person more susceptible to other diseases.