About one million people in the United States are treated in emergency rooms each year for traumatic brain injuries, resulting from traffic accidents, sports-related concussions, military injuries, and strokes. By the year 2030, according to the American Heart Association, almost 4 percent of U.S. adults will have a stroke.
- Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
- Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
- Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
- Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
- Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice
- Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance
- CBD reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke