The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. Researchers conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking.
CBD reduces cigarette consumption in tobacco smokers.
Abstract: The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. We conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking. 24 smokers were randomised to receive an inhaler of CBD (n=12) or placebo (n=12) for one week, they were instructed to use the inhaler when they felt the urge to smoke. Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by ~40% during treatment. Results also indicated some maintenance of this effect at follow-up. These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.
Published in Addict Behav. 2013 Sep;38(9):2433-6. doi: 10.1016/j.addbeh.2013.03.011. Epub 2013 Apr 1.
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Researchers led by Yasmin Hurd at Mount Sinai recently showed that acute ingestion of high doses of pure CBD (400-800 mg) dramatically reduced participants’ response to heroin triggers while simultaneously ameliorating anxiety.
145 People reported taking CBD for addiction 49% Female 48% Male 3% Prefer not to say
An unfortunate slogan of the cannabis legalization movement has been “Regulate cannabis like alcohol.” But cannabis, unlike alcohol, is not associated with domestic violence, sexual assault, liver toxicity, cancers, neurodegeneration, and the list goes on. Cannabinoids can, in fact, attenuate many of these issues, as described in a recent review. A group of Canadian scientists systematically reviewed publications about CBD as a drug for people abusing alcohol.
The endocannabinoid system is fundamental to addiction, but not in obvious ways. All sorts of cannabinoids appear to have anti-addictive properties: CBD, THCV, Rimonabant, THC. But Rimonabant acts by blocking the CB1 receptor, THC activates it, and CBD primarily functions in other ways.