Science

The Science of CBD

Cannabis has been at the center of one of the most exciting—and underreported—developments in modern science. Research on marijuana’s effects led directly to the discovery of a hitherto unknown biochemical communication system in the human body, the Endocannabiod System, which plays a crucial role in regulating our physiology, mood, and everyday experience.

How CBD Works

Cannabidiol (CBD), a non-psychoactive component of the cannabis plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out.

Terpenes and the "Entourage Effect"

Cannabis terpenes interact synergistically to create what scientists refer to as an “entourage effect” that magnifies the therapeutic benefits of the plant’s individual components—so that the medicinal impact of the whole plant is greater than the sum of its parts.

The Endocannabinoid System

Research on marijuana’s effects led directly to the discovery of a hitherto unknown biochemical communication system in the human body, the endocannabinoid system, which plays a crucial role in regulating our physiology, mood, and everyday experience.

Is "Pure" CBD Better?

Scientific studies have established that synthetic, single-molecule CBD has a narrow therapeutic window and requires high doses for efficacy as compared to whole-plant, cannabis-derived CBD.
A small rat perches on top of a bouqet of daisies on a wooden table.

Is CBD Toxic to the Liver?

The huge popularity of cannabidiol has helped to destigmatize the plant and restore its reputation as an important medicinal herb. But bogus science and inept reporting continue to distort how we understand the benefits and risks of CBD and cannabis.
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CBD & the Psychedelic Receptor

In a shorthand that drives scientists mad, serotonin is often called ‘the neurotransmitter of happiness.’ This tag is especially troublesome as more and more flaws become apparent in the ‘serotonin hypothesis’ of depression – the idea that depression is caused by a serotonin deficit, which a pill (a serotonin reuptake inhibitor) could correct.1  Serotonin is a complex molecule in the brain and the periphery with a vast and intricate receptor system classified into seven ma

Sequencing the Cannabis Genome

The Massachusetts-based company Medicinal Genomics has sequenced the entire genome of Cannabis sativa L. The announcement received much attention. But how will it impact research and public health?

Cannabis Science: What to Believe

Bias is baked into scientific research about cannabis. How can you tell what is worth reading, and what isn’t?

Is CBD an Endocannabinoid Reuptake Inhibitor?

Project CBD speaks with Matt Elmes, PhD, director of new product development at CannaCraft, about his post-doctoral research on CBD, fatty acid transport molecules, and the endocannabinoid system.
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CBD Survey Results: Cultivating Wellness

Who Is Using CBD and Why? Despite the huge public interest in CBD products, and an endless stream of media stoking that fire, there have been limited efforts to figure out exactly how and why people are using this darling compound of the cannabis world.