THC has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of CBD and terpenes to cannabis pharmacology and analgesia have been scientifically demonstrated.
This study examines the current knowledge of physiological and clinical effects of THC and CBD and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are also explored.
The misnamed Smart Approaches to Marijuana (SAM) recently produced a “fact sheet” entitled, Everything You Need to Know About CBD, that seeks to justify the continued prohibition of cannabis by misinforming the public about cannabidiol and THC.