Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: November 14, 2019
Three happy students looking at you with thumbs up in an university campus.
A letter published in the Journal of the American Medical Association (JAMA) highlighted that legalizing adult use of cannabis is correlated with lower rates of teen use. Read more
Posted: November 5, 2019
An illustration of a person in a white hazmat suit with a backpack-style sprayer on their back. They are standing and spraying on an aqua background.
The EPA has refused to provide pesticide regulations for the cannabis industry. So states have to create their own regulations by banning and “recommending” the pesticides they deem appropriate. A new study examines batches of cannabis that failed pesticide screening in Oregon.  Read more
Posted: November 4, 2019
An illustration of two doctors, on female-presenting and one male presenting. She carries an giant prescription pill bottle while he gives a thumbs up and carries a clipboard.
A recent publication described some aspects of the interaction between cannabidiol and the antiepileptic drug clobazam. But they’re a little late to the game.  Read more
Posted: October 29, 2019
An illustration of a subway car on an acqua background.
CBD has shown some promise in anxiety and panic disorders, from public speaking to schizophrenia. A group of London researchers followed up on these results with an experiment published in the Journal of Psychopharmacology. Read more
Posted: October 21, 2019
A cold glass of beer with cannabis leaf floated on top of the head, sits in front of an aqua and yellow background. The colors are split on an angle, and the beer sits on the split.
Confused about cannabis addiction and withdrawal? So are the experts. Researchers were recently surprised to find that cannabis use was not well correlated with its own supposed withdrawal syndrome. Read more

More quick hits

Posted: 7 months 2 weeks ago

The endocannabinoid system forms part of what makes us feel pleasure — from the runner’s high, eating good food, and according to new research singing. Saoirse O’Sullivan’s group at University of Nottingham (UK) examined the effects of singing and dancing on endocannabinoid levels.

Posted: 7 months 2 weeks ago

2-AG is the most abundant endocannabinoid. It is derived from the lipid membrane that separates a cell from its environment — a cell will cut 2-AG out of its membrane, allowing the molecule to drift to neighboring cells. Upon meeting those neighbors, it slips into their membrane, where it binds to

Posted: 7 months 2 weeks ago
Increased consideration of the public health impact of legalization has led to a closer look at cannabis’ impact on obesity. New research from Michigan supports an association between cannabis use and lower BMI.
Posted: 7 months 2 weeks ago
Danish researchers have found that cannabis users with schizophrenia experienced significantly fewer gut-related issues than those of non-cannabis users.
Posted: 7 months 3 weeks ago
Large doses of THC, CBD, and CBN could make processing some blood pressure drugs and Ritalin more difficult. Most of these cannabinoids aren’t consumed at doses large enough to affect the process but patients using large doses of CBD should monitor the metabolism of other drugs they’re taking.
Posted: 7 months 3 weeks ago
Ohio researchers found Chron’s Disease symptoms were 40-70% lower in patients using cannabis than non-users.
Posted: 7 months 3 weeks ago

Last week we wrote about a study on CBD and cancer. The authors suggested that CBD was fighting cancer cells by blocking a receptor called GPR55.

Posted: 7 months 3 weeks ago

The endocannabinoid system is fundamental to addiction, but not in obvious ways. All sorts of cannabinoids appear to have anti-addictive properties: CBD, THCV, Rimonabant, THC.

Posted: 7 months 3 weeks ago

The kidneys are a workhorse of the body, filtering nutrients from toxins. Oily cannabinoids like THC and CBD slip out of the kidneys’ filtration system, but they stop to interact with cannabinoid receptors that regulate kidney function.

Posted: 8 months 1 day ago
cancer cell and lab tray with dropper

Scientists in at Western New England University in Springfield, Massachusetts, briefly review 10 studies that shed light on how CBD might interact with cancer treatments.

Posted: 8 months 1 day ago

Sometimes, science fails to see the tree for the forest. Statistical significance and double-blind trials are important, but so is human experience. Case studies are meaningful. Case studies often portend future discovery. So the case study of two Brazilian brain cancer patients who successfully combined CBD with their cancer treatment should not be dismissed. In their report, Paula Dall’Stella and other doctors in São Paulo describe the typical treatment plan for patients with glioblastoma.

Posted: 8 months 1 day ago

Breast cancers are often classified by the receptors they express. The three most common breast cancer receptors respond to estrogen, progesterone, or epidermal growth factor. The latter include HER2-positive breast cancers. Identifying these receptors facilitates treatment. A study led by scientists in Spain indicates that the

Posted: 8 months 1 day ago
blue and yellow drawing of lungs

Doctors in the UK recently reported the case of an elderly man who’s lung cancer responded to CBD. The man — being 81 years old — decided against chemotherapy or radiation, which would worsen his quality of life without much hope for extending it. Four months after a CT scan, the tumor cross section had shrunk to nearly one tenth of its initial size! The doctors — obviously surprised — found out that the patient had begun using a CBD oil 2-3 months earlier.

Posted: 8 months 1 day ago

An “orphan receptor” is the term for a receptor in the body whose natural activator is not known.

Posted: 8 months 1 day ago

The first medical use of THC allowed by the FDA was the 1985 approval of isolate THC (Marinol) to treat nausea and vomiting from chemotherapy.

Posted: 8 months 1 week ago

Cannabidiol (CBD) is an astonishingly safe drug. Currently, the biggest safety concern is that at high doses it can alter the metabolism of other pharmaceuticals. That means CBD might amplify the toxicity of other drugs.

Posted: 8 months 1 week ago

In clinical research, cannabis is often set up to fail. Federal restrictions privilege studying isolated molecules from cannabis over the plant itself. And even when cannabis research is done, scientists are often forced to use low-quality weed from the National Institute of Drug Abuse.

Posted: 8 months 1 week ago

According to a recent study by University of Pensylvannia scientists, there were small or limited associations between [adolescent] cannabis use and structural brain measures. But even calling the effect small is aggrandizing harms. Their data didn’t support the notion that teens using cannabis causes any changes in the developing brain.

Posted: 8 months 1 week ago
Drawing of woman with abdominal pain

Adenomyosis is a menstrual complication that causes heavier bleeding and pain during a woman’s period. About one in five women suffer from it. As with most female diseases, it is poorly studied and consequently hard to treat. The

Posted: 8 months 1 week ago
A rat smoking weed

Preclinical studies are supposed to provide precise, controllable, and translational models for human diseases. But the manipulations that researchers use — like injecting a precise dose of THC into a rat — may sometimes miss important points. What if smoking and injection have different effects? How might this bias results? University of Florida researchers asked just that question, studying the effects of injected vs. smoked THC in rats. Injecting low doses of THC impaired memory.