Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: September 12, 2019
Cups of coffee with marijuana and roasted beans on a table
Some research has shown that caffeine can amplify the short-term forgetfulness caused by THC. A new study indicates that the caffeine may block other effect of cannabinoids. Read more
Posted: September 12, 2019
Marijuana leaves and a cup of coffee on white
It is increasingly recognized that cannabidiol can moderate many of the effects of THC, but the mechanisms by which CBD does this aren’t obvious. The neurotransmitter adenosine may be one important link. Read more
Posted: September 11, 2019
Close up pouring purified fresh drink water from the bottle on table in living room
Dosing CBD and other cannabinoids is challenging. An article in Molecules detailed the absorption and kinetics of a new formulation of self-emulsifying CBDRead more
Posted: September 10, 2019
Portrait of tender gentle romantic sweet lovely open-hearted african man showing big red heart in hands isolated on gray background
Researchers from eight different countries recently collaborated on an article warning about the dangers of teens falling in love. Read more
Posted: September 9, 2019
Close up portrait of beautiful young black woman smiling outdoors
The protective effect of cannabinoids for those living with Type 2 diabetes and obesity is particularly pronounced among people with schizophrenia. Why? Read more

More quick hits

Posted: 6 months 4 days ago

The first medical use of THC allowed by the FDA was the 1985 approval of isolate THC (Marinol) to treat nausea and vomiting from chemotherapy.

Posted: 6 months 1 week ago

Cannabidiol (CBD) is an astonishingly safe drug. Currently, the biggest safety concern is that at high doses it can alter the metabolism of other pharmaceuticals. That means CBD might amplify the toxicity of other drugs.

Posted: 6 months 1 week ago

In clinical research, cannabis is often set up to fail. Federal restrictions privilege studying isolated molecules from cannabis over the plant itself. And even when cannabis research is done, scientists are often forced to use low-quality weed from the National Institute of Drug Abuse.

Posted: 6 months 1 week ago

According to a recent study by University of Pensylvannia scientists, there were small or limited associations between [adolescent] cannabis use and structural brain measures. But even calling the effect small is aggrandizing harms. Their data didn’t support the notion that teens using cannabis causes any changes in the developing brain.

Posted: 6 months 1 week ago
Drawing of woman with abdominal pain

Adenomyosis is a menstrual complication that causes heavier bleeding and pain during a woman’s period. About one in five women suffer from it. As with most female diseases, it is poorly studied and consequently hard to treat. The

Posted: 6 months 1 week ago
A rat smoking weed

Preclinical studies are supposed to provide precise, controllable, and translational models for human diseases. But the manipulations that researchers use — like injecting a precise dose of THC into a rat — may sometimes miss important points. What if smoking and injection have different effects? How might this bias results? University of Florida researchers asked just that question, studying the effects of injected vs. smoked THC in rats. Injecting low doses of THC impaired memory.

Posted: 6 months 1 week ago
Rainbow Boa Snake

Panic, as a mental health disorder, results from overactive stress hormones, hypersensitivity to certain neurotransmitters, and a desensitization to the parasympathetic system — which is supposed to quell the fight-or-flight reaction after a threat has disappeared. New research from Brazilian scientsts in São Paulo examined how endocannabinoids, specifically anandamide, plays a role in panic-like reactions in mice.

Posted: 6 months 2 weeks ago

A few researchers have tried to answer this question, with mixed results. Alex Stevens at the University of Kent reanalyzed the data from a 2015 paper which claimed that liberal cannabis policies increase teen use. The data included a multi-year survey of over 170,000 people in 38 different countries.

Posted: 6 months 2 weeks ago

Most everyone has had the experience of biting into a spicy pepper and feeling heat permeate their mouth. This feeling comes from the activation of TRPV (pronounced trip-vee) receptors. These are ion channels that sense stimuli like heat, pressure, light, acidity, herbs, and toxins. TRPV receptors exist on many kinds of cells — from taste buds to neurons.

Posted: 6 months 2 weeks ago
Drawing of child with stomach ache

Cannabis is used by many individuals with inflammatory bowel disorder (IBD), which includes conditions like Crohn’s disease and ulcerative colitis. IBD is not uncommon among people younger than 18, and about one in three of these individuals use cannabis to manage symptoms such as nausea, pain, and fatigue.

Posted: 6 months 2 weeks ago
Black widow on leaf

Scientists from the Netherlands recently published the protocol for an upcoming study examining how CBD might be helpful in treating specific phobias. The endocannabinoid system is required for eliminating fearful memories, or at least making them palatable. But why have they only published their methods?

Posted: 6 months 3 weeks ago

A number of surveys have asked doctors what they know about cannabis and how comfortable they feel talking with patients about it. A similar survey was recently conducted about CBD and dogs among over 2000 veterinarians in the United States. Less than half of vets were comfortable talking to clients about CBD for pets.

Posted: 6 months 3 weeks ago
Improved brain function

THC and other cannabinoids are known to induce neurogenesis — the creation of new neurons — in the brain. There are reasons to believe that this can positively influence diseases like dementia or traumatic brain injury, as well as the ability to learn. Malaysian researchers recently probed the question, does THC improve cognition by inducing neurogenesis? Yes, but only at the right dose.

Posted: 6 months 3 weeks ago
Ketamine
Ketamine is a dissociative anaesthetic that has shown some promise for treating severe depression. Those effects could be because of its interactions with the endocannabinoid system.
Posted: 6 months 3 weeks ago

Systemic lupus erythomatosus, often simply called lupus, is a severe autoimmune disorder where the immune system attacks the nucleus of cells — their genetic control center. Problems can be expressed anywhere in the body, though rashes in the skin, joints, and vital organs are most common. Treatment of lupus generally requires intense immunosuppresive drugs, often targeting inflammatory molecules called interferons. But these drugs make a person more susceptible to other diseases.

Posted: 6 months 4 weeks ago
Hoarding money

The US is considered to have one of the least efficient medical systems among developed countries.

Posted: 7 months 17 hours ago

An unfortunate slogan of the cannabis legalization movement has been “Regulate cannabis like alcohol.” But cannabis, unlike alcohol, is not associated with domestic violence, sexual assault, liver toxicity, cancers, neurodegeneration, and the list goes on. Cannabinoids can, in fact, attenuate many of these issues, as described in a recent review.

Posted: 7 months 17 hours ago
Marijuana leaf and handcuffs

Possession of cannabis in the UK is currently punishable by up to 5 years in prison and an unlimited fine. On January 23, 2019, the Royal College of Psychiatrists in London attempted to hold a debate on the British laws that criminalize cannabis use. But it didn’t take place because none of the psychiatrists present were willing to argue for criminalization.

Posted: 7 months 17 hours ago
stop sign and crossing guard

Driving accidents cause about 60,000 deaths in the US each year, and nearly all of these are due to driver errors. Regulators are still trying to understand the risks associated with driving while high. Canadian epidemiologist recently analyzed data from the stoner holiday 4/20, finding that there was up to a 12% increase in the number of fatal accidents that that day. This is within typical daily variations, suggesting that, if there is an increase in crash risk, it is small.

Posted: 7 months 17 hours ago

Nonsteroidal antiinflammatory drugs (NSAIDs) are one of the most common classes of painkillers, which includes aspirin, ibuprofen, celecoxib, and other pharmaceuticals. Their primary target is an enzyme called cyclooxygenase-2 (COX-2), which metabolizes many lipids (including endocannabinoids!) into a class of inflammatory molecules called prostaglandins.