Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: September 12, 2019
Cups of coffee with marijuana and roasted beans on a table
Some research has shown that caffeine can amplify the short-term forgetfulness caused by THC. A new study indicates that the caffeine may block other effect of cannabinoids. Read more
Posted: September 12, 2019
Marijuana leaves and a cup of coffee on white
It is increasingly recognized that cannabidiol can moderate many of the effects of THC, but the mechanisms by which CBD does this aren’t obvious. The neurotransmitter adenosine may be one important link. Read more
Posted: September 11, 2019
Close up pouring purified fresh drink water from the bottle on table in living room
Dosing CBD and other cannabinoids is challenging. An article in Molecules detailed the absorption and kinetics of a new formulation of self-emulsifying CBDRead more
Posted: September 10, 2019
Portrait of tender gentle romantic sweet lovely open-hearted african man showing big red heart in hands isolated on gray background
Researchers from eight different countries recently collaborated on an article warning about the dangers of teens falling in love. Read more
Posted: September 9, 2019
Close up portrait of beautiful young black woman smiling outdoors
The protective effect of cannabinoids for those living with Type 2 diabetes and obesity is particularly pronounced among people with schizophrenia. Why? Read more

More quick hits

Posted: 5 months 1 week ago
The last four years have seen a glut of patents filed for compounds that interact with the CB1 receptor. Agonists, antagonists, and allosteric modulators, oh my!
Posted: 5 months 1 week ago

A new study suggests that marijuana use among working 12th graders has increased since legalization in Colorado, and therefore interventions to reduce youth use are necessary. But working 12th graders were the only subgroup whose cannabis use increased since legalization. Everyone else — working 8th and 10th graders and all unemployed survey participants — used cannabis at a lower rate.

Posted: 5 months 1 week ago

The gateway theory of addiction is a slippery slope fallacy. It argues that when people are introduced to mild drugs like cannabis, they later escalate to dangerous drugs like amphetamines and opioids. In the era of reefer madness, this was an excuse to demonize cannabis by associating it with lethal drugs. Although the theory is wrong, there are a few real aspects of addiction it captures.

Posted: 5 months 1 week ago

When a receptor is overactive — because of a drug or disease — the body attempts to normalize activity by internalizing the receptor, hiding it from molecules at the cell surface. Internalization is a key homeostatic mechanism. But a receptor’s degree of activation doesn’t perfectly parallel the subsequent internalization.

Posted: 5 months 1 week ago

A synthetic cannabinoid pharmaceutical called Rimonabant was briefly approved in Europe as an anti-obesity drug. Rimonabant inhibits the CB1

Posted: 5 months 2 weeks ago

A mother’s diet while she’s pregnant is known to affect the child’s eventual food preferences. A new animal study from scientists in the U.S. and Brazil examines how a high-fat diet during pregnancy influences the offspring’s predisposition to obesity and related complications later in life, and this appears to be mediated by changes in the

Posted: 5 months 2 weeks ago

The endocannabinoid system forms part of what makes us feel pleasure — from the runner’s high, eating good food, and according to new research singing. Saoirse O’Sullivan’s group at University of Nottingham (UK) examined the effects of singing and dancing on endocannabinoid levels.

Posted: 5 months 2 weeks ago

2-AG is the most abundant endocannabinoid. It is derived from the lipid membrane that separates a cell from its environment — a cell will cut 2-AG out of its membrane, allowing the molecule to drift to neighboring cells. Upon meeting those neighbors, it slips into their membrane, where it binds to

Posted: 5 months 2 weeks ago
Increased consideration of the public health impact of legalization has led to a closer look at cannabis’ impact on obesity. New research from Michigan supports an association between cannabis use and lower BMI.
Posted: 5 months 2 weeks ago
Danish researchers have found that cannabis users with schizophrenia experienced significantly fewer gut-related issues than those of non-cannabis users.
Posted: 5 months 3 weeks ago
Large doses of THC, CBD, and CBN could make processing some blood pressure drugs and Ritalin more difficult. Most of these cannabinoids aren’t consumed at doses large enough to affect the process but patients using large doses of CBD should monitor the metabolism of other drugs they’re taking.
Posted: 5 months 3 weeks ago
Ohio researchers found Chron’s Disease symptoms were 40-70% lower in patients using cannabis than non-users.
Posted: 5 months 3 weeks ago

Last week we wrote about a study on CBD and cancer. The authors suggested that CBD was fighting cancer cells by blocking a receptor called GPR55.

Posted: 5 months 3 weeks ago

The endocannabinoid system is fundamental to addiction, but not in obvious ways. All sorts of cannabinoids appear to have anti-addictive properties: CBD, THCV, Rimonabant, THC.

Posted: 5 months 3 weeks ago

The kidneys are a workhorse of the body, filtering nutrients from toxins. Oily cannabinoids like THC and CBD slip out of the kidneys’ filtration system, but they stop to interact with cannabinoid receptors that regulate kidney function.

Posted: 6 months 4 days ago
cancer cell and lab tray with dropper

Scientists in at Western New England University in Springfield, Massachusetts, briefly review 10 studies that shed light on how CBD might interact with cancer treatments.

Posted: 6 months 4 days ago

Sometimes, science fails to see the tree for the forest. Statistical significance and double-blind trials are important, but so is human experience. Case studies are meaningful. Case studies often portend future discovery. So the case study of two Brazilian brain cancer patients who successfully combined CBD with their cancer treatment should not be dismissed. In their report, Paula Dall’Stella and other doctors in São Paulo describe the typical treatment plan for patients with glioblastoma.

Posted: 6 months 4 days ago

Breast cancers are often classified by the receptors they express. The three most common breast cancer receptors respond to estrogen, progesterone, or epidermal growth factor. The latter include HER2-positive breast cancers. Identifying these receptors facilitates treatment. A study led by scientists in Spain indicates that the

Posted: 6 months 4 days ago
blue and yellow drawing of lungs

Doctors in the UK recently reported the case of an elderly man who’s lung cancer responded to CBD. The man — being 81 years old — decided against chemotherapy or radiation, which would worsen his quality of life without much hope for extending it. Four months after a CT scan, the tumor cross section had shrunk to nearly one tenth of its initial size! The doctors — obviously surprised — found out that the patient had begun using a CBD oil 2-3 months earlier.

Posted: 6 months 4 days ago

An “orphan receptor” is the term for a receptor in the body whose natural activator is not known.