Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: November 15, 2019
Data from a study out of the University of Toronto shows that while high cannabis users consistently drive more slowly than those who don’t use. And when users aren’t high, they drive more cautiously and consistently than non-users. Researchers try to make this sound like a bad thing - but is it? Read more
Posted: November 14, 2019
Three happy students looking at you with thumbs up in an university campus.
A letter published in the Journal of the American Medical Association (JAMA) highlighted that legalizing adult use of cannabis is correlated with lower rates of teen use. Read more
Posted: November 5, 2019
An illustration of a person in a white hazmat suit with a backpack-style sprayer on their back. They are standing and spraying on an aqua background.
The EPA has refused to provide pesticide regulations for the cannabis industry. So states have to create their own regulations by banning and “recommending” the pesticides they deem appropriate. A new study examines batches of cannabis that failed pesticide screening in Oregon.  Read more
Posted: November 4, 2019
An illustration of two doctors, on female-presenting and one male presenting. She carries an giant prescription pill bottle while he gives a thumbs up and carries a clipboard.
A recent publication described some aspects of the interaction between cannabidiol and the antiepileptic drug clobazam. But they’re a little late to the game.  Read more
Posted: October 29, 2019
An illustration of a subway car on an acqua background.
CBD has shown some promise in anxiety and panic disorders, from public speaking to schizophrenia. A group of London researchers followed up on these results with an experiment published in the Journal of Psychopharmacology. Read more

More quick hits

Posted: 6 months 2 weeks ago

A pilot study recently demonstrated that cannabis extracts can be safely used to ameliorate symptoms of severe dementia. Swiss researchers at Geneva University Hospitals decided to use cannabinoids to help ten patients with severe dementia. They took a 2:1

Posted: 6 months 2 weeks ago

There are curious cases of people who feel no pain or have extreme resistance to discomfort. These individuals are often studied by researchers who hope to develop better methods of pain management. One such woman was discovered after she recovered from a highly painful wrist surgery using Tylenol alone. As researchers at the University College of London found out, she had a history of this sort of endurance, and it appeared to have been passed on to her son. With her consent, they ran genetic tests, identifying two mutation in genes related to FAAH.

Posted: 6 months 2 weeks ago

As CBD and recreational cannabis have gained considerable momentum, important aspects of medical marijuana are falling by the wayside. The magnified focus on economic incentives and tax revenue has overshadowed the significance of cannabis as medicine.

Posted: 6 months 3 weeks ago

In 2017, Michigan’s government founded a commission to recommend policy on cannabis and driving, specifically how to set THC limits. Two years later, in March 2019, they released their conclusion: [T]he Commission finds there is no scientifically supported threshold of ∆9-THC bodily content that would be indicative of impaired driving (emphasis added).

Posted: 6 months 3 weeks ago

Cannabinoids play a diverse role in addiction. They confer some of the euphoric feelings of many drugs, but also help eliminate memories that trigger cravings. The also regulate dopamine in a part of the brain called the ventral tegmental area (VTA). Normally, dopamine release in the VTA helps orient animals, including humans, to new kinds of stimuli.

Posted: 6 months 3 weeks ago
Tobacco is a known fetal toxin. Cannabis is not. The negative effects that have been associated with using cannabis during pregnancy could be because of simultaneous use of other substances, like tobacco.
Posted: 6 months 3 weeks ago

“What about the children?” is a mantra that has been used to propel prohibition with misplaced fear. Scientists and politicians increasingly warn about the dangers of using cannabis during pregnancy. There’s only one issue: data doesn’t back them up. But a lack of evidence has never stopped the tides of prohibition.

Posted: 6 months 3 weeks ago

A new study from researchers at San Diego State University examined the interaction between cannabinoids and alcohol on the fetus. The scientists used pregnant rats to avoid the ethical implications of exposing babies to drugs. Fetal alcohol exposure impaired coordination and motor control of the rats, which lasted throughout adolescence. But CP-55,940 — a synthetic

Posted: 6 months 3 weeks ago

There is little evidence to show a directly harmful effect of cannabis in pregnancy. However, cannabinoids consistently amplify the toxic effects of nicotine and alcohol on the fetus. Preclinical research suggests one possible reason: activating the CB2

Posted: 6 months 3 weeks ago
CBD could protect against hypoxic ischemia, a complication that prevents a baby from getting enough oxygen during birth. Researchers in Spain show that its protective effects could have to do with the dimerization of CB2 and 5-HT1A.
Posted: 7 months 3 days ago

Legalization has led to lower rates of cannabis use among teens, while middle-aged and elderly adults are adopting extracts for the aches of aging.

Posted: 7 months 3 days ago
Epidiolex makers studied how liver impairment affected metabolism of CBD. They found that while hundreds of mgs of CBD were still safely tolerated, it was metabolized more poorly. Doses should be lowered depending on the severity of liver impairment.
Posted: 7 months 3 days ago

Heavy or even moderate drinking causes maladaptions in humans, ranging from cardiovascular disease to cirrhosis. Underlying many of these ill effects is alcohol’s ability to amplify inflammation. But the immune system is immensely complex, and “inflammation” is a catch-all term that accounts for most degenerative and age-related disease, so it is important to distinguish the specific molecules promoting inflammation. Interleukins are a class of proteins that orchestrate the movement of immune cells – most, but not all, increase inflammation.

Posted: 7 months 4 days ago

A new study from researchers at Yale University suggests that an antipsychotic called haloperidol decreases the psychoactive effects of THC. Reading between the lines in research, it’s always important to check the dose administered. These scientists gave participants an i.v. injection of THC (0.0286 mg THC per kg bodyweight, to be exact). For an average adult in the U.S. that means injecting about 2 mg of THC.

Posted: 7 months 4 days ago

One of the many political hurdles that cannabis researchers face is the supply chain – for decades the National Institute on Drug Abuse (NIDA) has been the sole producer of “research grade” cannabis.

Posted: 7 months 1 week ago
The last four years have seen a glut of patents filed for compounds that interact with the CB1 receptor. Agonists, antagonists, and allosteric modulators, oh my!
Posted: 7 months 1 week ago

A new study suggests that marijuana use among working 12th graders has increased since legalization in Colorado, and therefore interventions to reduce youth use are necessary. But working 12th graders were the only subgroup whose cannabis use increased since legalization. Everyone else — working 8th and 10th graders and all unemployed survey participants — used cannabis at a lower rate.

Posted: 7 months 1 week ago

The gateway theory of addiction is a slippery slope fallacy. It argues that when people are introduced to mild drugs like cannabis, they later escalate to dangerous drugs like amphetamines and opioids. In the era of reefer madness, this was an excuse to demonize cannabis by associating it with lethal drugs. Although the theory is wrong, there are a few real aspects of addiction it captures.

Posted: 7 months 1 week ago

When a receptor is overactive — because of a drug or disease — the body attempts to normalize activity by internalizing the receptor, hiding it from molecules at the cell surface. Internalization is a key homeostatic mechanism. But a receptor’s degree of activation doesn’t perfectly parallel the subsequent internalization.

Posted: 7 months 1 week ago

A synthetic cannabinoid pharmaceutical called Rimonabant was briefly approved in Europe as an anti-obesity drug. Rimonabant inhibits the CB1