Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: November 15, 2019
Data from a study out of the University of Toronto shows that while high cannabis users consistently drive more slowly than those who don’t use. And when users aren’t high, they drive more cautiously and consistently than non-users. Researchers try to make this sound like a bad thing - but is it? Read more
Posted: November 14, 2019
Three happy students looking at you with thumbs up in an university campus.
A letter published in the Journal of the American Medical Association (JAMA) highlighted that legalizing adult use of cannabis is correlated with lower rates of teen use. Read more
Posted: November 5, 2019
An illustration of a person in a white hazmat suit with a backpack-style sprayer on their back. They are standing and spraying on an aqua background.
The EPA has refused to provide pesticide regulations for the cannabis industry. So states have to create their own regulations by banning and “recommending” the pesticides they deem appropriate. A new study examines batches of cannabis that failed pesticide screening in Oregon.  Read more
Posted: November 4, 2019
An illustration of two doctors, on female-presenting and one male presenting. She carries an giant prescription pill bottle while he gives a thumbs up and carries a clipboard.
A recent publication described some aspects of the interaction between cannabidiol and the antiepileptic drug clobazam. But they’re a little late to the game.  Read more
Posted: October 29, 2019
An illustration of a subway car on an acqua background.
CBD has shown some promise in anxiety and panic disorders, from public speaking to schizophrenia. A group of London researchers followed up on these results with an experiment published in the Journal of Psychopharmacology. Read more

More quick hits

Posted: 5 months 2 weeks ago
Police officer writing a ticket.
The push to criminalize cannabis has always revolved around race. As legalization movements gain momentum, it is important to pay back a debt owed to those who were most harmed by the drug war.
Posted: 5 months 2 weeks ago
 A cannabis branch and a syringe on a pink background
Researchers led by Yasmin Hurd at Mount Sinai recently showed that acute ingestion of high doses of pure CBD (400-800 mg) dramatically reduced participants’ response to heroin triggers while simultaneously ameliorating anxiety.
Posted: 5 months 3 weeks ago
Human liver anatomy with DNA structure, 3D render.
When the gene encoding FABP1 is deleted from rats, the rate of THC metabolism is dramatically slowed.
Posted: 5 months 3 weeks ago
Assorted pharmaceutical medicine pills, tablets and capsules and bottle on blue background.
Many drugs have been proposed as “treatment” for cannabis addiction, from pure THC or CBD-rich cannabis, to Ambien. These studies often employ participants who are not trying to quit, and overlook the harms associated with the replacement medication.
Posted: 5 months 3 weeks ago
ULcerative colitis. Frustrated man hugging his belly and keeping eyes closed. Disturbed male having pain in stomach.
CBD has shown promise in a number of gastrointestinal disorders, particularly autoimmune problems like Crohn’s. But a recent clinical trial of CBD may put a damper on hopes for treating ulcerative colitis.
Posted: 5 months 3 weeks ago
Oxycodone pills on a blue background.

Opioids leave much to be desired in medical treatment. They are highly addictive, very lethal, and not all that effective for treating chronic pain.

Posted: 5 months 3 weeks ago
A darkened hand holds a bag of synthetic cannabis
Synthetic cannabinoids (sCBs) are a class of designer drugs meant to interact with the endocannabinoid system. British researchers recently published a report on the types of sCBs found among those who have died in the UK since 2014.
Posted: 5 months 3 weeks ago
Conceptual image of liver damage as a result of drugs, viruses, toxins, bacteria, parasites, 3D illustration - Illustration
Posted: 5 months 3 weeks ago
Stethoscope on note book with Menopause words as medical concept

Hormone replacement therapy is used to reduce some of the symptoms of menopause. Although it can reduce problems like osteoporosis, hot flashes and depression, hormonal treatments come with risks including an increased likelihood of stroke and heart attack. Among those who use hormone therapy, scientists tend to believe there is a “critical window” where hormone replacement can reduce depression and the worsening memory associated with menopause. A new study from researchers in Xi’an, China, indicates that activating CB1 may prolong this window.

Posted: 5 months 3 weeks ago
Joyful mature man holding a joint and looking at the camera isolated on white background

The elderly are the fastest growing population of cannabis users. But how do hospice workers feel about their patients using cannabis? A recent survey by pharmacists at the University of Maryland asked palliative care practitioners about their opinions on cannabis use among hospice patients. Over 90% of workers support the use of cannabis, but most physicians did not recommend cannabis to their patients.

Posted: 6 months 6 days ago

Robert Randall was the first U.S. citizen to legally access cannabis based on medical necessity since the start of prohibition.

Posted: 6 months 6 days ago

Phytocannabinoids consistently confuse scientists because of the multiplicity of their actions. CBD, for example, binds to a handful of neurotransmitter receptors, as well as hormone receptors, ion channels, and a variety of enzymes. Receptors without a known endogenous ligand are called “orphan” receptors.

Posted: 6 months 6 days ago
CBD and anandamide

It has been known for some time that CBD acutely increases anandamide levels. The enhancement of

Posted: 6 months 1 week ago

If THC makes people forgetful while they’re high, one might reasonably expect that blocking the CB1 receptor that mediates the high will promote focus and the ability to learn. But is this true?

Posted: 6 months 1 week ago

It’s increasingly recognized that the runner’s high, which used to be attributed to endorphins, is conferred partly by endocannabinoids in the brain. In response to the stress of exercise, the brain produces anandamide, “the bliss chemical” which provides that feeling of elation along with pain reduction and health benefits.

Posted: 6 months 1 week ago
Very high doses of CBD (2-3 grams) might interact with tacrolimus, an immunosuppressive drug used in organ transplant patients.
Posted: 6 months 1 week ago

CBD is clearly a useful medicine in the treatment of some types of epilepsy, yet patients are faced with dilemmas when they must decide which product to use, how to incorporate it with other medications, and how to begin dosing.

Posted: 6 months 1 week ago

Many prohibitionist arguments are being flipped on their heads. CBD’s anti-anxiety effects have replaced much of the reefer madness mentality. Rather than causing lung cancer, marijuana appears to have anti-cancer activity, if anything. And in spite of the gateway theory, whereby casual cannabis use supposedly escalates to heroin, we find that cannabis helps to treat pain and reduce opiate use.

Posted: 6 months 1 week ago
Placebo effect cannabinoid receptors

Throughout history, cannabis has been described as a treatment for hundreds of different conditions. If scientists find it hard to believe cannabis can do so much, they may chalk up the results as just a placebo. But the placebo effect is powerful. It accounts for roughly half of the efficacy of opioids and antidepressants.

Posted: 6 months 1 week ago

A major benefit of legalization is regulation (at least in theory). Cannabis in a legal market can be held to safety standards such as the absence of dangerous pesticides. While autonomous community-enforced regulation can exist without government intervention, this does not happen at the global scale which the cannabis industry has reached today. So how well are governments doing with their pesticides regulations?