Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: January 1, 2020
Two dropper bottles lay on an aqua background. Their pink labels read "Acid" and "LSD," respectively.
One of the biggest issues with an unregulated drug market is the presence of adulterants. Many of the adulterants found in samples of LSD are potentially lethal - unlike the drug they intend to mimic. Read more
Posted: November 26, 2019
A rat looks out of a hear-shaped hole in a pink background.
Uruguayan researchers found that a low dose of cannabis increased some mating behaviors, a high dose reduced them, and any dose increased sensitivity to pleasurable touch.  Read more
Posted: November 15, 2019
A cannabis leaf sits on the middle console of a car with a car key laid on top. There's a sun spot in the upper left hand corner of the photograph.
High cannabis users consistently drive more slowly than those who don’t use. And when users aren’t high, they drive more cautiously and consistently than non-users. Researchers try to make this sound like a bad thing. Read more
Posted: November 14, 2019
Three happy students looking at you with thumbs up in an university campus.
A letter published in the Journal of the American Medical Association (JAMA) highlighted that legalizing adult use of cannabis is correlated with lower rates of teen use. Read more
Posted: November 5, 2019
An illustration of a person in a white hazmat suit with a backpack-style sprayer on their back. They are standing and spraying on an aqua background.
The EPA has refused to provide pesticide regulations for the cannabis industry. So states have to create their own regulations by banning and “recommending” the pesticides they deem appropriate. A new study examines batches of cannabis that failed pesticide screening in Oregon.  Read more

More quick hits

Posted: June 2, 2019

The development of legal cannabis is associated with lower teen use and higher adult use. But many scientists, hesitant to give up a lifetime of prohibition, spin their data to emphasize danger.

Posted: June 2, 2019

There has been a spate of recent articles on exercise and cannabis. Part of the runner’s high is attributable to endocannabinoid release. In Colorado, cannabis users are more physically active, on average.

Posted: May 29, 2019
Police officer writing a ticket.
The push to criminalize cannabis has always revolved around race. As legalization movements gain momentum, it is important to pay back a debt owed to those who were most harmed by the drug war.
Posted: May 29, 2019
 A cannabis branch and a syringe on a pink background
Researchers led by Yasmin Hurd at Mount Sinai recently showed that acute ingestion of high doses of pure CBD (400-800 mg) dramatically reduced participants’ response to heroin triggers while simultaneously ameliorating anxiety.
Posted: May 28, 2019
Human liver anatomy with DNA structure, 3D render.
When the gene encoding FABP1 is deleted from rats, the rate of THC metabolism is dramatically slowed.
Posted: May 28, 2019
Assorted pharmaceutical medicine pills, tablets and capsules and bottle on blue background.
Many drugs have been proposed as “treatment” for cannabis addiction, from pure THC or CBD-rich cannabis, to Ambien. These studies often employ participants who are not trying to quit, and overlook the harms associated with the replacement medication.
Posted: May 28, 2019
ULcerative colitis. Frustrated man hugging his belly and keeping eyes closed. Disturbed male having pain in stomach.
CBD has shown promise in a number of gastrointestinal disorders, particularly autoimmune problems like Crohn’s. But a recent clinical trial of CBD may put a damper on hopes for treating ulcerative colitis.
Posted: May 22, 2019
Oxycodone pills on a blue background.

Opioids leave much to be desired in medical treatment. They are highly addictive, very lethal, and not all that effective for treating chronic pain.

Posted: May 22, 2019
A darkened hand holds a bag of synthetic cannabis
Synthetic cannabinoids (sCBs) are a class of designer drugs meant to interact with the endocannabinoid system. British researchers recently published a report on the types of sCBs found among those who have died in the UK since 2014.
Posted: May 22, 2019
Conceptual image of liver damage as a result of drugs, viruses, toxins, bacteria, parasites, 3D illustration - Illustration
Posted: May 22, 2019
Stethoscope on note book with Menopause words as medical concept
A new study indicates that activating CB1 may prolong the window during which hormone replacement therapy can reduce depression and improve worsening memory associated with menopause.
Posted: May 22, 2019
Joyful mature man holding a joint and looking at the camera isolated on white background

The elderly are the fastest growing population of cannabis users. But how do hospice workers feel about their patients using cannabis? A recent survey by pharmacists at the University of Maryland asked palliative care practitioners about their opinions on cannabis use among hospice patients. Over 90% of workers support the use of cannabis, but most physicians did not recommend cannabis to their patients.

Posted: May 13, 2019

Robert Randall was the first U.S. citizen to legally access cannabis based on medical necessity since the start of prohibition.

Posted: May 13, 2019

Phytocannabinoids consistently confuse scientists because of the multiplicity of their actions. CBD, for example, binds to a handful of neurotransmitter receptors, as well as hormone receptors, ion channels, and a variety of enzymes. Receptors without a known endogenous ligand are called “orphan” receptors.

Posted: May 13, 2019
CBD and anandamide

It has been known for some time that CBD acutely increases anandamide levels. The enhancement of

Posted: May 11, 2019
An illustration of a pink brain wearing glasses looking at a laptop with a stack of book sitting nearby. There's a lightbulb lit in the upper lefthand corner and some mathematical symbols scribbled on the background.
If THC makes people forgetful while they’re high, one might reasonably expect that blocking the CB1 receptor that mediates the high will promote focus and the ability to learn. But is this true?
Posted: May 11, 2019

It’s increasingly recognized that the runner’s high, which used to be attributed to endorphins, is conferred partly by endocannabinoids in the brain. In response to the stress of exercise, the brain produces anandamide, “the bliss chemical” which provides that feeling of elation along with pain reduction and health benefits.

Posted: May 8, 2019
Very high doses of CBD (2-3 grams) might interact with tacrolimus, an immunosuppressive drug used in organ transplant patients.
Posted: May 8, 2019

CBD is clearly a useful medicine in the treatment of some types of epilepsy, yet patients are faced with dilemmas when they must decide which product to use, how to incorporate it with other medications, and how to begin dosing.

Posted: May 8, 2019

Many prohibitionist arguments are being flipped on their heads. CBD’s anti-anxiety effects have replaced much of the reefer madness mentality. Rather than causing lung cancer, marijuana appears to have anti-cancer activity, if anything. And in spite of the gateway theory, whereby casual cannabis use supposedly escalates to heroin, we find that cannabis helps to treat pain and reduce opiate use.