Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: September 12, 2019
Cups of coffee with marijuana and roasted beans on a table
Some research has shown that caffeine can amplify the short-term forgetfulness caused by THC. A new study indicates that the caffeine may block other effect of cannabinoids. Read more
Posted: September 12, 2019
Marijuana leaves and a cup of coffee on white
It is increasingly recognized that cannabidiol can moderate many of the effects of THC, but the mechanisms by which CBD does this aren’t obvious. The neurotransmitter adenosine may be one important link. Read more
Posted: September 11, 2019
Close up pouring purified fresh drink water from the bottle on table in living room
Dosing CBD and other cannabinoids is challenging. An article in Molecules detailed the absorption and kinetics of a new formulation of self-emulsifying CBDRead more
Posted: September 10, 2019
Portrait of tender gentle romantic sweet lovely open-hearted african man showing big red heart in hands isolated on gray background
Researchers from eight different countries recently collaborated on an article warning about the dangers of teens falling in love. Read more
Posted: September 9, 2019
Close up portrait of beautiful young black woman smiling outdoors
The protective effect of cannabinoids for those living with Type 2 diabetes and obesity is particularly pronounced among people with schizophrenia. Why? Read more

More quick hits

Posted: 4 months 2 weeks ago
Very high doses of CBD (2-3 grams) might interact with tacrolimus, an immunosuppressive drug used in organ transplant patients.
Posted: 4 months 2 weeks ago

CBD is clearly a useful medicine in the treatment of some types of epilepsy, yet patients are faced with dilemmas when they must decide which product to use, how to incorporate it with other medications, and how to begin dosing.

Posted: 4 months 2 weeks ago

Many prohibitionist arguments are being flipped on their heads. CBD’s anti-anxiety effects have replaced much of the reefer madness mentality. Rather than causing lung cancer, marijuana appears to have anti-cancer activity, if anything. And in spite of the gateway theory, whereby casual cannabis use supposedly escalates to heroin, we find that cannabis helps to treat pain and reduce opiate use.

Posted: 4 months 2 weeks ago
Placebo effect cannabinoid receptors

Throughout history, cannabis has been described as a treatment for hundreds of different conditions. If scientists find it hard to believe cannabis can do so much, they may chalk up the results as just a placebo. But the placebo effect is powerful. It accounts for roughly half of the efficacy of opioids and antidepressants.

Posted: 4 months 2 weeks ago

A major benefit of legalization is regulation (at least in theory). Cannabis in a legal market can be held to safety standards such as the absence of dangerous pesticides. While autonomous community-enforced regulation can exist without government intervention, this does not happen at the global scale which the cannabis industry has reached today. So how well are governments doing with their pesticides regulations?

Posted: 4 months 3 weeks ago

A pilot study recently demonstrated that cannabis extracts can be safely used to ameliorate symptoms of severe dementia. Swiss researchers at Geneva University Hospitals decided to use cannabinoids to help ten patients with severe dementia. They took a 2:1

Posted: 4 months 3 weeks ago

There are curious cases of people who feel no pain or have extreme resistance to discomfort. These individuals are often studied by researchers who hope to develop better methods of pain management. One such woman was discovered after she recovered from a highly painful wrist surgery using Tylenol alone. As researchers at the University College of London found out, she had a history of this sort of endurance, and it appeared to have been passed on to her son. With her consent, they ran genetic tests, identifying two mutation in genes related to FAAH.

Posted: 4 months 3 weeks ago

As CBD and recreational cannabis have gained considerable momentum, important aspects of medical marijuana are falling by the wayside. The magnified focus on economic incentives and tax revenue has overshadowed the significance of cannabis as medicine.

Posted: 4 months 3 weeks ago

In 2017, Michigan’s government founded a commission to recommend policy on cannabis and driving, specifically how to set THC limits. Two years later, in March 2019, they released their conclusion: [T]he Commission finds there is no scientifically supported threshold of ∆9-THC bodily content that would be indicative of impaired driving (emphasis added).

Posted: 4 months 3 weeks ago

Cannabinoids play a diverse role in addiction. They confer some of the euphoric feelings of many drugs, but also help eliminate memories that trigger cravings. The also regulate dopamine in a part of the brain called the ventral tegmental area (VTA). Normally, dopamine release in the VTA helps orient animals, including humans, to new kinds of stimuli.

Posted: 4 months 4 weeks ago
Tobacco is a known fetal toxin. Cannabis is not. The negative effects that have been associated with using cannabis during pregnancy could be because of simultaneous use of other substances, like tobacco.
Posted: 4 months 4 weeks ago

“What about the children?” is a mantra that has been used to propel prohibition with misplaced fear. Scientists and politicians increasingly warn about the dangers of using cannabis during pregnancy. There’s only one issue: data doesn’t back them up. But a lack of evidence has never stopped the tides of prohibition.

Posted: 4 months 4 weeks ago

A new study from researchers at San Diego State University examined the interaction between cannabinoids and alcohol on the fetus. The scientists used pregnant rats to avoid the ethical implications of exposing babies to drugs. Fetal alcohol exposure impaired coordination and motor control of the rats, which lasted throughout adolescence. But CP-55,940 — a synthetic

Posted: 5 months 3 hours ago

There is little evidence to show a directly harmful effect of cannabis in pregnancy. However, cannabinoids consistently amplify the toxic effects of nicotine and alcohol on the fetus. Preclinical research suggests one possible reason: activating the CB2

Posted: 5 months 3 hours ago
CBD could protect against hypoxic ischemia, a complication that prevents a baby from getting enough oxygen during birth. Researchers in Spain show that its protective effects could have to do with the dimerization of CB2 and 5-HT1A.
Posted: 5 months 6 days ago

Legalization has led to lower rates of cannabis use among teens, while middle-aged and elderly adults are adopting extracts for the aches of aging.

Posted: 5 months 6 days ago
Epidiolex makers studied how liver impairment affected metabolism of CBD. They found that while hundreds of mgs of CBD were still safely tolerated, it was metabolized more poorly. Doses should be lowered depending on the severity of liver impairment.
Posted: 5 months 6 days ago

Heavy or even moderate drinking causes maladaptions in humans, ranging from cardiovascular disease to cirrhosis. Underlying many of these ill effects is alcohol’s ability to amplify inflammation. But the immune system is immensely complex, and “inflammation” is a catch-all term that accounts for most degenerative and age-related disease, so it is important to distinguish the specific molecules promoting inflammation. Interleukins are a class of proteins that orchestrate the movement of immune cells – most, but not all, increase inflammation.

Posted: 5 months 6 days ago

A new study from researchers at Yale University suggests that an antipsychotic called haloperidol decreases the psychoactive effects of THC. Reading between the lines in research, it’s always important to check the dose administered. These scientists gave participants an i.v. injection of THC (0.0286 mg THC per kg bodyweight, to be exact). For an average adult in the U.S. that means injecting about 2 mg of THC.

Posted: 5 months 6 days ago

One of the many political hurdles that cannabis researchers face is the supply chain – for decades the National Institute on Drug Abuse (NIDA) has been the sole producer of “research grade” cannabis.