Quick Hits

Welcome to Project CBD Quick Hits, where we collect some of the most interesting and informative tidbits of research into cannabis over the past week.
Posted: January 1, 2020
Two dropper bottles lay on an aqua background. Their pink labels read "Acid" and "LSD," respectively.
One of the biggest issues with an unregulated drug market is the presence of adulterants. Many of the adulterants found in samples of LSD are potentially lethal - unlike the drug they intend to mimic. Read more
Posted: November 26, 2019
A rat looks out of a hear-shaped hole in a pink background.
Uruguayan researchers found that a low dose of cannabis increased some mating behaviors, a high dose reduced them, and any dose increased sensitivity to pleasurable touch.  Read more
Posted: November 15, 2019
A cannabis leaf sits on the middle console of a car with a car key laid on top. There's a sun spot in the upper left hand corner of the photograph.
High cannabis users consistently drive more slowly than those who don’t use. And when users aren’t high, they drive more cautiously and consistently than non-users. Researchers try to make this sound like a bad thing. Read more
Posted: November 14, 2019
Three happy students looking at you with thumbs up in an university campus.
A letter published in the Journal of the American Medical Association (JAMA) highlighted that legalizing adult use of cannabis is correlated with lower rates of teen use. Read more
Posted: November 5, 2019
An illustration of a person in a white hazmat suit with a backpack-style sprayer on their back. They are standing and spraying on an aqua background.
The EPA has refused to provide pesticide regulations for the cannabis industry. So states have to create their own regulations by banning and “recommending” the pesticides they deem appropriate. A new study examines batches of cannabis that failed pesticide screening in Oregon.  Read more

More quick hits

Posted: July 16, 2019
Caryophyllene and leafy greens
Terpenoids — the volatile compounds that give many plants their smell — appear to confer some of the medical effects of cannabis. Caryophyllene (BCP) and its derivative caryophyllene oxide (BCPO) are particularly significant terpenoids found in many green leafy vegetables.
Posted: July 16, 2019
CBD for brain cancer; alternative treatment
Although cannabinoids have shown promise for epilepsy in general, Epidiolex is only approved for two kinds of childhood epilepsy. But this may be more a reflection of the FDA’s drug approval process than of the conditions for which CBD helps.
Posted: June 30, 2019
Doctors at the Cleveland Clinic Foundation recently examined how cannabis users faired through pancreatitis compared to the general population. They surveyed records of 2.8 million acute pancreatitis patients over 10 years, and the results were dramatic.
Posted: June 29, 2019
How do cannabinoids affect memory and learning? It seems like a simple question, but scientists study its answer in complex ways. The kind of memory in question, the species tested, the animals’ age and sex, and so on, all affect the answer. So, scientists at Kings College in London compiled 195 articles on cannabinoids and memory for review. ⁠
Posted: June 28, 2019
Without dedicated attention to those most harmed by police enforcement of drug laws, their situation might not improve. A new study highlights how youth have been left behind because legalization often does not reduce penalties for underage possession.
Posted: June 25, 2019
A third of patients still do not find effective methods for preventing seizures. A recent Canadian study has demonstrated synergy between the anti-seizure activity of THC and CBD.
Posted: June 25, 2019
Scientists in Australia and New Zealand recently examined how a synthetic cannabinoid, CUMYL-4CN-BINACA, causes seizures.
Posted: June 22, 2019
"Fibromyalgia" handwritten on a diagnosis pad, surrounded by heaps of white and pink pills, on a white background.
An Israeli observational study of 367 people using cannabis for fibromyalgia shows promising results. Many subjects reported significant decreases in pain and increases in quality of life.
Posted: June 21, 2019
Illustration of a woman with curly purple hair holding two masks: one happy and one sad.

Bipolar disorder is rarely considered from our growing perspective of the endocannabinoid system in mental health. Iranian researchers at Kerman University recently reviewed the beneficial and harmful aspects of endocannabinoids in this disease.

Posted: June 18, 2019
Bud of marijuana balanced on the point of a school pencil, in a row of pencils with their eraers pointing up, isolated on white.
California researchers tried to threaten and belittle middle-schoolers into fearing cannabis. Not only does the tactic not work, and it can increase chances of risky behavior to more dangerous drugs.
Posted: June 18, 2019
A doctor in a lab coat holds a cola of cannabis flower and a tincture bottole in their hands.
Donald Abrams is a San Francisco oncologist who has instigated significant cannabis research, including early studies on the safety of combining cannabis with HIV therapy or opioids. He laid out the potential of cannabis in cancer care in a recent piece titled “Should Oncologists recommend cannabis?” In a word, yes.
Posted: June 18, 2019
Man hands holding a white paper sheet with two faced head over a crowded street background.
People have been studying the link between cannabis and schizophrenia for over a century. Research has not established strong evidence that cannabis causes schizophrenia, although there is an association. A new paper highlights some limitations of these studies.
Posted: June 12, 2019
cbd research - cannabis research

Part of why doctors remain wary of cannabis medicine is the lack of randomized, double-blind, placebo controlled trials — the gold standard for medical research. Because of cannabis’ status as an illicit drug, research is often relegated to retrospective surveys, which are useful but more likely to be biased. But there are methods in between these two schemes, such as open-label trials.

Posted: June 12, 2019
CBD for organ transplants

Candidates for organ transplant are thoroughly screened, and illicit substance use is usually disqualifying. But cannabis is well established as a medicine (as it has been for millennia) and should not prevent patients from receiving a necessary transplant. Doctors at a pediatric hospital in Delaware recently described the thought process around allowing or prohibiting cannabis use.

Posted: June 10, 2019
CBD for nausea

Preventing nausea is a common medical use of cannabis. But nausea is a multi-faceted feeling. Motion sickness, morning sickness, the flu, or chemotherapy all cause slightly different versions of this discomfort.

Posted: June 9, 2019
contaminants in hemp

Hemp is a bioaccumulator — it tends to absorb heavy metals from soil, leaving the ground clean by collecting contaminants in its body. When intended for human consumption, this is obviously a problem. But as a means for cleansing land of industrial toxins, hemp is quite promising.

Posted: June 7, 2019
Pesticides on cannabis

Organophosphates are a class of insecticides like chlorpyrifos and soman. Sarin, used as a chemical weapon, is also an organophosphate. Many of these are neurotoxic, owing to their ability to amplify the neurotransmitter acetylcholine, which paralyzes insects and causes their death. A recent study from medical researchers in Maryland and Pennsylvania described the human toxicity in detail and explained why cannabinoids may be protective for humans.

Posted: June 2, 2019

Researchers have modulated cannabinoid CB1 receptors in addiction treatment in order to affect cravings, the formation of habits, one’s sensitivity to triggers, withdrawal symptoms, and the pleasure one derives from drug use. Now scientists at the National Institute on Alcohol Abuse and Alcoholism have added a new factor to the list: feeling satiated.

Posted: June 2, 2019

Cannabinoids have been proposed for numerous neurodegenerative disorders. As a matter of fact, scientists employed by the US government filed a patent in 2001 for Cannabinoids as antioxidants and neuroprotectants, citing their potential for treating Alzheimer’s disease among others.

Posted: June 2, 2019

Driving under the influence of cannabis (DUIC) is framed as a major risk associated with legalizing cannabis. Studies on cannabis and driving suggest that lighting up before getting behind the wheel increases crash risk between 25-40%.