Preventing Pain with Orphan Receptors

Preventing Pain with Orphan Receptors

Mexican and Texan scientists describe the modern approach to pain treatment and propose a future role of cannabinoids, GPR18, and GPR55 in preventing pain
Black man covering his eyes

Phytocannabinoids consistently confuse scientists because of the multiplicity of their actions. CBD, for example, binds to a handful of neurotransmitter receptors, as well as hormone receptors, ion channels, and a variety of enzymes. Receptors without a known endogenous ligand are called “orphan” receptors. GPR18 is involved in ocular-pressure (and hence glaucoma treatment) as well as cardiovascular function. The receptor named GPR55 is relevant in cancer pathology, and works with the CB2 receptor to regulate immune migration. In a review published in Frontiers in Pharmacology, Mexican and Texan scientists describe the modern approach to pain treatment and propose a future role of cannabinoids, GPR18, and GPR55 in preventing pain.

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