Orphan Receptors in Cancer

Orphan Receptors in Cancer

An “orphan receptor” is the term for a receptor in the body whose natural activator is not known.
cancer cells being attacked

An “orphan receptor” is the term for a receptor in the body whose natural activator is not known. GPR55 is a G-protein coupled orphan receptor that interacts with the endocannabinoid system. CBD appears to inhibit GPR55, while endocannabinoids may activate it. Researchers in the UK and Italy collaborated on a study of GPR55 in pancreatic cancer. Activating GPR55 increased the proliferation and metastasis of cancer cells, while inhibiting GPR55 with CBD or another molecule slowed tumor progression. Mice treated with CBD and the chemo gemcitabine survived nearly three times longer than the mice that didn’t receive CBD. Since CBD affects many different proteins, it’s hard to be sure that GPR55 is the main reason for CBD’s protective activity. The scientists emphasize that CBD and gemcitabine — which are both approved for use in humans — should be tested in clinical trials. Previous research has shown that activating GPR55 stimulates the immune system, opposing the anti-inflammatory immuno-modulating effect of the CB2 cannabinoid receptor.

Find CBD near you

Browse hundreds of retail locations for quality CBD products.

Search

News & Reports

Final installment of a 5-part series on Hemp & Native American Sovereignty

Top Conditions

In compiling a list of conditions that CBD may help, we examined hundreds of peer-reviewed articles in scientific journals.

Cannabis Conversations

Project CBD talks with Dr. Bonni Goldstein about whole plant cannabis remedies, nonintoxicating cannabinoids, and cancer care for children.
Expert cannabis botanist and geneticist Ryan Lee talks to Project CBD about breeding cannabis, THC & CBD content, and how to interpret lab data.
Project CBD speaks with Dr. Rachel Knox about "endocannabinology," THC/CBD synergies, and whole food nutrition.

Top Stories