Below are additional science abstracts on cannabis and cancer.
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Bladder Cancer
Brain Cancer
- Cannabidiol enhances the inhibitory effects of delta9-THC on human glioblastoma cell proliferation and survival
- Antitumor effects of CBD, a nonpsychoactive cannabinoid, on human glioma cell lines
- Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
- CBD inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
- Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
- Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
- CBD inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
- Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
- Synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture
- Cannabis improved survival of patients with aggressive brain cancer in controlled clinical study
Breast Cancer
- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
- CBD induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
- Pathways mediating the effects of CBD on the reduction of breast cancer cell proliferation, invasion, and metastasis
- CBD as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
- Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
- CBD-A mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells
Colon Cancer
- Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
- Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of CBD
- Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
Endocrine Cancer
- Endocannabinoids in endocrine and related tumours
- A comparative study on CBD-induced apoptosis in murine thymocytes and EL-4 thymoma cells
Kaposi Sarcoma
Leukemia
- CBD-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
- CBD-Induced Apoptosis in Human Leukemia Cells
- Cannabidiol Reduces Leukemic Cell Size - But Is It Important?
Lung Cancer
- CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
- COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
- Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of CBD on human lung cancer cells
Prostate Cancer
- Towards the use of non-psychoactive cannabinoids for prostate cancer
- In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines
- Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
Skin Cancer
Recommended reading
Dr. Donald Abrams laid out the potential of cannabis in cancer care in a recent piece titled “Should Oncologists recommend cannabis?”
Breast cancers are often classified by the receptors they express. The three most common breast cancer receptors respond to estrogen, progesterone, or epidermal growth factor. The latter include HER2-positive breast cancers. Identifying these receptors facilitates treatment. A study led by scientists in Spain indicates that the endocannabinoid system plays an important role in the treatment of HER2-positive cancer.
Sometimes, science fails to see the tree for the forest. Statistical significance and double-blind trials are important, but so is human experience. Case studies are meaningful. Case studies often portend future discovery. So the case study of two Brazilian brain cancer patients who successfully combined CBD with their cancer treatment should not be dismissed. In their report, Paula Dall’Stella and other doctors in São Paulo describe the typical treatment plan for patients with glioblastoma.
