Depression
Depression
Depression is a serious condition that can lead to a variety of emotional and physical problems and decrease one’s ability to function. Symptoms include fatigue, anxiety, irritability, restlessness, loss of enjoyment, appetite changes, changes in sleep patterns, and thoughts of suicide.
Thanks to myristicin and other mescaline-like molecules, nutmeg is hallucinogenic in large doses.
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In early 2019 Project CBD began collecting responses to a survey designed to figure out who is using CBD, how and why, what kinds of products they are consuming, and whether or not CBD is working for them.
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CBD oil seems to be everywhere these days. But how much do we actually know about cannabidiol?
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A new study indicates that activating CB1 may prolong the window during which hormone replacement therapy can reduce depression and improve worsening memory associated with menopause.
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It has been known for some time that CBD acutely increases endogenous cannabinoid levels.
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Endocannabinoid levels are often diminished in people with depression, and restoring cannabinoid tone with exercise seems promising.
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The placebo effect accounts for roughly half of the efficacy of opioids and antidepressants.
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High doses of THC are hallucinogenic, and microdosing LSD is a lot like CBD. These mighty molecules can relieve human suffering and they act through the endocannabinoid system.
Article
Saoirse O'Sullivan's group at University of Nottingham (UK) examined the effects of singing and dancing on endocannabinoid levels
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Science abstracts on CBD and Depression
- Endocannabinoid system dysfunction in mood and related disorders
- Antidepressant-like and anxiolytic-like effects of CBD
- The endocannabinoid system and the treatment of mood and anxiety disorders
- Endocannabinoid signaling in the etiology and treatment of major depressive illness
- Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors
- >Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
- Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa
- Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
- Serum contents of endocannabinoids are correlated with blood pressure in depressed women
- The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants
- Antidepressants and changes in concentration of endocannabinoids and n-acylethanolamines in rat brain structures
- Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors
- Prohedonic effect of CBD in a rat model of depression
- Antidepressant-like and anxiolytic-like effects of CBD
These links are from third-party sites and are provided as a courtesy to the reader.
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THE ESSENTIAL GUIDE TO CBD
By the Editors of Reader’s Digest & Project CBD: Everything You Need to Know About What It Helps, Where to Buy It, and How to Take It.