Are psychedelic drugs therapeutic? How do psychedelics relate to medical cannabis? Psychedelic drugs and cannabis compounds tap into how we function biologically and spiritually on a deep level. Both have shown promise for treating trauma, addictive behaviors, and depression. The antidepressant effects of psychedelics and cannabis are contingent on enhanced neuroplasticity and neurogenesis (the creation of new brain cells), which are regulated by the endocannabinoid system. Whereas high doses of THC (the principal psychoactive component of cannabis) can cause vivid psychedelic-like effects, microdosing LSD and psilocybin is more akin to taking CBD. Join Martin A. Lee, Project. CBD director, for the discussion.