Adrian Devitt-Lee, Project CBD’s chief science writer, is the winner of the Norbert Wiener Award in Mathematics from Tufts University, where he graduated with a MS in Math and a BA in Chemistry. He is the co-author of several articles in peer-reviewed publications, including the Journal of Physiology, F1000Research, SIAM Journal on Applied Mathematics, and Physica A. Devitt-Lee’s report on cannabinoid-pharmaceutical interactions was published in Sonoma Medicine. As a R&D intern with Medicinal Genomics, he identified mutations in the CBDA synthase gene in plant varieties. He also performed cell culture, time-lapse microscopy, flow cytometry and RNA extraction on cancer cells as an intern with the California Pacific Medical Center in San Francisco. As a senior research associate with CannaCraft, Inc., Devitt-Lee researched pesticide and solvent safety and provided regulatory input to California government officials. He is currently a chemistry researcher at the University College in London.
One broad effect of CBD and THC is the stimulation of neurogenesis — the production and integration of new neurons in the brain. Researchers in Barcelona, Spain, recently studied how CBD would affect addiction and learning in mice when neurogenesis was artificially prevented.
Recent research has indicated a role of endocannabinoids in endometriosis and related diseases. A study published in Frontiers in Oncology sought to determine whether endometrial cancer could be predicted by someone’s levels of the two canonical cannabinoid receptors (CB1 and CB2) and three related fatty acids (anandamide, OEA, and PEA).
Terpenoids — the volatile compounds that give many plants their smell — appear to confer some of the medical effects of cannabis. Caryophyllene (BCP) and its derivative caryophyllene oxide (BCPO) are particularly significant terpenoids found in many green leafy vegetables.
Although cannabinoids have shown promise for epilepsy in general, Epidiolex is only approved for two kinds of childhood epilepsy. But this may be more a reflection of the FDA’s drug approval process than of the conditions for which CBD helps.
Doctors at the Cleveland Clinic Foundation recently examined how cannabis users faired through pancreatitis compared to the general population. They surveyed records of 2.8 million acute pancreatitis patients over 10 years, and the results were dramatic.
How do cannabinoids affect memory and learning? It seems like a simple question, but scientists study its answer in complex ways. The kind of memory in question, the species tested, the animals’ age and sex, and so on, all affect the answer. So, scientists at Kings College in London compiled 195 articles on cannabinoids and memory for review.
Without dedicated attention to those most harmed by police enforcement of drug laws, their situation might not improve. A new study highlights how youth have been left behind because legalization often does not reduce penalties for underage possession.
A third of patients still do not find effective methods for preventing seizures. A recent Canadian study has demonstrated synergy between the anti-seizure activity of THC and CBD.