Adrian Devitt-Lee, Project CBD’s chief science writer, is the winner of the Norbert Wiener Award in Mathematics from Tufts University, where he graduated with a MS in Math and a BA in Chemistry. He is the co-author of several articles in peer-reviewed publications, including the Journal of Physiology, F1000Research, SIAM Journal on Applied Mathematics, and Physica A. Devitt-Lee’s report on cannabinoid-pharmaceutical interactions was published in Sonoma Medicine. As a R&D intern with Medicinal Genomics, he identified mutations in the CBDA synthase gene in plant varieties. He also performed cell culture, time-lapse microscopy, flow cytometry and RNA extraction on cancer cells as an intern with the California Pacific Medical Center in San Francisco. As a senior research associate with CannaCraft, Inc., Devitt-Lee researched pesticide and solvent safety and provided regulatory input to California government officials. He is currently pursuing a research Ph.D in chemistry at the University College in London.
Synthetic cannabinoids are not as safe as cannabinoids from plants, and can lead to deadly consequences.
While CBD can interact negatively with other drugs when dosed at high levels, evidence of use at recreational levels has not shown the same risks.
In a rodent model, CB1 activation lengthened the therapeutic window for treating some symptoms related to menopause. Increasing CB1 expression made menopause therapies more effective.
Researchers have recently described the role of cannabinoids in healing wounds on the cornea. Activating the orphan receptor GPR18 was shown to speed up the rate of wound healing on the cornea in a rodent model.
Orphan receptors GPR18 and GPR55 have been indicated for their role in pain management. Activation of these receptors with cannabinoids could represent a new approach for pain treatment.
CBD’s ability to increase anandamide levels may be responsible for some of CBD’s medical properties. Not only does it inhibit the compound that naturally breaks down anandamide, but new research shows that it can also promote anadamide’s synthesis.
Learning involves both forging new neural connections and pruning ones that are no longer necessary. Blocking CB1 activation may impair learning ability by blocking its ability to prune unhelpful connections.